منابع مشابه
Mutations in G proteins and G protein-coupled receptors in endocrine disease.
G Proteins couple receptors for diverse extracellular signals to effecters such as enzymes and ion channels. The majority of polypeptide hormones, all monoamine neurotransmitters, PGs, and even extracellular Ca’+ signal their target cells through G protein-coupled receptors (GPCR). In the past few years, mutations in G proteins and GPCR have been identified as the causes of several endocrine di...
متن کاملEndocrine diseases in animals.
BACKGROUND Several endocrine disorders that affect humans also occur as endocrinopathies in companion animals. Spontaneous endocrine disorders in animals may provide valuable information for their counterparts in human endocrinology. For example, the discovery of progesterone-induced growth hormone production in the mammary gland of dogs may have important consequences for understanding the pat...
متن کاملInactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.
Since the discovery of the first rhodopsin mutation that causes retinitis pigmentosa in 1990, significant progresses have been made in elucidating the pathophysiology of diseases caused by inactivating mutations of G protein-coupled receptors (GPCRs). This review aims to compile the compelling evidence accumulated during the past 15 years demonstrating the etiologies of more than a dozen diseas...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2001
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1450543